Publication: Inflammatory responses to secondary organic aerosols (SOA) generated from biogenic and anthropogenic precursors
Publication - Inflammatory responses to secondary organic aerosols (SOA) generated from biogenic and anthropogenic precursors
Title:
Inflammatory responses to secondary organic aerosols (SOA) generated from biogenic and anthropogenic precursors
DOI:
10.5194/acp-17-11423-2017
Publication Year:
2017
Author list:
Tuet, W. Y.
Journal Short Name:
Atmos. Chem. Phys.
Publisher:
Copernicus Publications
Abstract
Cardiopulmonary health implications resulting from exposure to secondary organic aerosols (SOA), which comprise a significant fraction of ambient particulate matter (PM), have received increasing interest in recent years. In this study, alveolar macrophages were exposed to SOA generated from the photooxidation of biogenic and anthropogenic precursors (isoprene, a-pinene, b-caryophyllene, pentadecane, m-xylene, and naphthalene) under different formation conditions (RO2+HO2 vs. RO2+NO dominant, dry vs. humid). Various cellular responses were measured, including reactive oxygen and nitrogen species (ROS/RNS) production and secreted levels of cytokines, tumor necrosis factor-a (TNF-a) and interleukin-6 (IL-6). SOA precursor identity and formation condition affected all measured responses in a hydrocarbon-specific manner. With the exception of naphthalene SOA, cellular responses followed a trend where TNF-a levels reached a plateau with increasing IL-6 levels. ROS/RNS levels were consistent with relative levels of TNF-a and IL-6, due to their respective inflammatory and anti-inflammatory effects. Exposure to naphthalene SOA, whose aromatic-ring-containing products may trigger different cellular pathways, induced higher levels of TNF-a and ROS/RNS than suggested by the trend. Distinct cellular response patterns were identified for hydrocarbons whose photooxidation products shared similar chemical functionalities and structures, which suggests that the chemical structure (carbon chain length and functionalities) of photooxidation products may be important for determining cellular effects. A positive nonlinear correlation was also detected between ROS/RNS levels and previously measured DTT (dithiothreitol) activities for SOA samples. In the context of ambient samples collected during summer and winter in the greater Atlanta area, all laboratory-generated SOA produced similar or higher levels of ROS/RNS and DTT activities. These results suggest that the health effects of SOA are important considerations for understanding the health implications of ambient aerosols.Additional Notes
Experiments (18)
ID | Name | Start date | Experiment Category | Reaction Type | Reactant(s) | Oxidant Name | Temperature | Humidity | Type of Seed | RO2 Main Fate | Data Sets (count) | Actions |
---|---|---|---|---|---|---|---|---|---|---|---|---|
286 | Ng Research Group_20160127_BETA-CARYOPHYLLENE_Hydroxyl radical_Ammonium sulfate_dry | 2016-01-27 | Aerosol formation | Photooxidation | BETA-CARYOPHYLLENE | Hydroxyl radical | 24-27 | 1-4 | Ammonium sulfate | HO2 | 4 | Download |
287 | Ng Research Group_20160325_ALPHA-PINENE_Hydroxyl radical_Ammonium sulfate_36%RH | 2016-03-25 | Aerosol formation | Photooxidation | ALPHA-PINENE | Hydroxyl radical | 24-27 | 40-32 | Ammonium sulfate | HO2 | 4 | Download |
288 | Ng Research Group_20160412_ALPHA-PINENE_Hydroxyl radical_Ammonium sulfate_dry | 2016-04-12 | Aerosol formation | Photooxidation | ALPHA-PINENE | Hydroxyl radical | 24-27 | 1-10 | Ammonium sulfate | NO | 7 | Download |
289 | Ng Research Group_20160123_ALPHA-PINENE_Hydroxyl radical_Ammonium sulfate_dry | 2016-01-23 | Aerosol formation | Photooxidation | ALPHA-PINENE | Hydroxyl radical | 24-27 | 1-4 | Ammonium sulfate | HO2 | 4 | Download |
290 | Ng Research Group_20160323_BETA-CARYOPHYLLENE_Hydroxyl radical_Ammonium sulfate_36%RH | 2016-03-23 | Aerosol formation | Photooxidation | BETA-CARYOPHYLLENE | Hydroxyl radical | 24-27 | 32-43 | Ammonium sulfate | HO2 | 4 | Download |
291 | Ng Research Group_20160416_BETA-CARYOPHYLLENE_Hydroxyl radical_Ammonium sulfate_dry | 2016-04-16 | Aerosol formation | Photooxidation | BETA-CARYOPHYLLENE | Hydroxyl radical | 24-27 | 1-6 | Ammonium sulfate | NO | 7 | Download |
292 | Ng Research Group_20160331_ISOPRENE_Hydroxyl radical_1:2 MgSO4/H2SO4_dry | 2016-03-31 | Aerosol formation | Photooxidation | ISOPRENE | Hydroxyl radical | 24-27 | 7-12 | 1:2 MgSO4/H2SO4 | HO2 | 4 | Download |
293 | Ng Research Group_20160420_ISOPRENE_Hydroxyl radical_Ammonium sulfate_dry | 2016-04-20 | Aerosol formation | Photooxidation | ISOPRENE | Hydroxyl radical | 24-27 | 1-10 | Ammonium sulfate | NO | 7 | Download |
294 | Ng Research Group_20160129_naphthalene_Hydroxyl radical_Ammonium sulfate_dry | 2016-01-29 | Aerosol formation | Photooxidation | naphthalene | Hydroxyl radical | 24-27 | 4-5 | Ammonium sulfate | HO2 | 3 | Download |
295 | Ng Research Group_20160329_naphthalene_Hydroxyl radical_Ammonium sulfate_39%RH | 2016-03-29 | Aerosol formation | Photooxidation | naphthalene | Hydroxyl radical | 24-27 | 32-46 | Ammonium sulfate | HO2 | 4 | Download |
296 | Ng Research Group_20160502_naphthalene_Hydroxyl radical_Ammonium sulfate_dry | 2016-05-02 | Aerosol formation | Photooxidation | naphthalene | Hydroxyl radical | 24-27 | 1-9 | Ammonium sulfate | NO | 7 | Download |
297 | Ng Research Group_20160321_M-XYLENE_Hydroxyl radical_Ammonium sulfate_36%RH | 2016-03-21 | Aerosol formation | Photooxidation | M-XYLENE | Hydroxyl radical | 24-27 | 26-46 | Ammonium sulfate | HO2 | 4 | Download |
298 | Ng Research Group_20160428_M-XYLENE_Hydroxyl radical_Ammonium sulfate_dry | 2016-04-28 | Aerosol formation | Photooxidation | M-XYLENE | Hydroxyl radical | 24-27 | 1-8 | Ammonium sulfate | NO | 7 | Download |
299 | Ng Research Group_20160510_Pentadecane_Hydroxyl radical_Ammonium sulfate_dry | 2016-05-10 | Aerosol formation | Photooxidation | Pentadecane | Hydroxyl radical | 24-27 | 1-8 | Ammonium sulfate | NO | 7 | Download |
300 | Ng Research Group_20160130_ISOPRENE_Hydroxyl radical_Ammonium sulfate_dry | 2016-01-30 | Aerosol formation | Photooxidation | ISOPRENE | Hydroxyl radical | 24-27 | 1-2 | Ammonium sulfate | HO2 | 3 | Download |
301 | Ng Research Group_20160126_M-XYLENE_Hydroxyl radical_Ammonium sulfate_dry | 2016-01-26 | Aerosol formation | Photooxidation | M-XYLENE | Hydroxyl radical | 24-27 | 1-2 | Ammonium sulfate | HO2 | 4 | Download |
302 | Ng Research Group_20160126_Pentadecane_Hydroxyl radical_Ammonium sulfate_dry | 2016-01-26 | Aerosol formation | Photooxidation | Pentadecane | Hydroxyl radical | 24-27 | 2-5 | Ammonium sulfate | HO2 | 4 | Download |
303 | Ng Research Group_20160324_Pentadecane_Hydroxyl radical_Ammonium sulfate_40%RH | 2016-03-24 | Aerosol formation | Photooxidation | Pentadecane | Hydroxyl radical | 24-27 | 35-45 | Ammonium sulfate | HO2 | 4 | Download |